Injectables
Biostimulators
Injectables that aim to support your skin's own collagen, for gradual, natural-looking firmness and definition.
At a glance
- Appointment
- Varies
- We'll tell you how long to allow when you book
- Results
- Gradual
- Building over weeks to months
- Lasting
- Varies
- From 6 months to 3 years, by product
- Downtime
- Little
- Swelling or bruising, clearing within 2 weeks
- Sessions
- Varies
- Sculptra is a series over several months
- Price from
- £300
- Free 20-minute consultation
Written using information from the American Academy of Dermatology, the U.S. Food and Drug Administration, the Plastic Surgery Practice and published research. Last reviewed October 2026. How we wrote this page
What biostimulators are
Biostimulators are injectables that aim to prompt your skin's own collagen over the months after treatment, for gradual support and firmness.
We offer six. HArmonyCa combines hyaluronic acid, which gives some lift straight away, with calcium hydroxylapatite. Sculptra is poly-L-lactic acid, given as a series of injections over several months. Radiesse is calcium hydroxylapatite. PINKLLA is described as poly-L-lactic acid with polynucleotides; product details: TBC. Ellansé and Gouri are polycaprolactone (PCL).
One important difference from hyaluronic acid filler: calcium hydroxylapatite, in Radiesse and HArmonyCa, can't be dissolved. That makes a complication more complex to treat, and it's something we'll talk through with you before you decide. The same applies to polycaprolactone, in Ellansé and Gouri: the enzyme that dissolves HA filler works only on hyaluronic acid.
| Option | What it is | Typical course | Price |
|---|---|---|---|
| HArmonyCa | Hyaluronic acid with calcium hydroxylapatite, for the mid and lower face | Planned with you | £649 |
| Sculptra | Poly-L-lactic acid. Results build over weeks, and can last 1 to 3 years | A series over several months | £529 |
| Radiesse | Calcium hydroxylapatite. Results can last 6 months to 1 year | Planned with you | £599 |
| PINKLLA | Described as poly-L-lactic acid with polynucleotides. Product details: TBC | 1 or 2 sessions | £300 |
| Ellansé M | Tiny spheres of polycaprolactone in a gel, made by Sinclair. The gel is absorbed over about 6 to 8 weeks and the spheres prompt collagen. The M version is designed to last about 2 years | Planned with you | £429 |
| Gouri | Liquid polycaprolactone without particles, made by Dexlevo, which spreads through the skin after injection. It's newer, and little has been published about it yet | 1 session, or a course of 3 | £349 |
Who it’s for
Adults only
Treatment is only for adults aged 18 and over.
Often a good fit if you
- have mild to moderate loss of firmness or volume in your face
- want gradual, natural-looking support rather than a dramatic change
- understand that calcium hydroxylapatite and polycaprolactone can't be dissolved
Not suitable, or we’ll wait, if you
- are under 18
- are pregnant or breastfeeding
- have a skin infection, spots or a cold sore in the area
- are allergic to any ingredient, including lidocaine, a local anaesthetic
If a filler or a skin booster would suit you better, we'll tell you at your consultation.
What happens on the day
-
Step 1: Consultation and assessment
We look closely at your face, talk through what you'd like to change and go through your medical history, then suggest the product that suits you.
-
Step 2: Preparing your skin
Your skin is cleansed and prepared.
-
Step 3: The treatment
The product is injected in small amounts into the planned areas.
-
Step 4: Straight afterwards
Some swelling, redness or bruising is normal. You'll get aftercare advice, including the warning signs to look out for.
Recovery and results
How many sessions you need depends on the product, the area and your skin. We'll plan yours at your consultation.
-
Straight away
HArmonyCa and Radiesse give some lift straight away.
-
The first 2 weeks
Redness, swelling, tenderness and bruising usually clear within 7 to 14 days.
-
Over the following months
Results build as collagen forms. With HArmonyCa, the peak effect is at 3 to 6 months.
-
Longer term
Results last from about 6 months to 3 years, depending on the product.
Aftercare
Please do
- Contact us straight away if you have increasing pain, or skin that turns white, blue or dusky. If your vision changes, call 999 or go to A&E.
- After Sculptra, gently massage the area for about 5 minutes several times a day for 1 to 2 weeks, if we advise you to.
- Let any swelling settle before judging your result.
| Avoid | For |
|---|---|
| Strenuous exercise | Until the next day |
| Sun, sunbeds and tanning | While swelling settles |
Risks and side effects
- Common and expected
- Redness, swelling, tenderness and bruising, usually clearing within 7 to 14 days.
- Less common
- Lumps or nodules under the skin. With calcium hydroxylapatite, side effects were reported in about 3 in 100 treatments, almost all of them nodules, and most weren't visible and settled on their own. Nodules can also follow poly-L-lactic acid, and lumps or hardening can follow polycaprolactone, mostly when it's placed too close to the surface.
- Rare but serious
- The product can block a blood vessel, which needs urgent expert treatment. Because calcium hydroxylapatite and polycaprolactone can't be dissolved, this is more complex to manage than with hyaluronic acid filler alone.
Worried after your treatment?
If anything about your skin worries you, contact us straight away on WhatsApp (opens WhatsApp) or call 07532 895989.
Prices
Biostimulators
| Treatment | Price |
|---|---|
| HArmonyCa | £649 |
| Sculptra | £529 |
| Radiesse | £599 |
| PINKLLA, 1 session | £300 |
| PINKLLA, 2 sessions | £550 |
| Gouri, 1 session | £349 |
| Gouri, 3 sessions | £899 |
| Ellansé M | £429 |
Your 20-minute consultation is free. We’ll confirm your final price and plan before any treatment.
Your questions
What is a biostimulator?
An injectable that aims to support your skin's own collagen over the months after treatment.
How is it different from filler?
Hyaluronic acid filler adds volume straight away and can be dissolved. Biostimulators work more gradually, and calcium hydroxylapatite and polycaprolactone can't be dissolved.
How long do results last?
It depends on the product: about 6 months to 1 year for Radiesse, and 1 to 3 years for Sculptra. HArmonyCa results lasted up to about a year in studies, and Ellansé M is designed to last about 2 years.
Which one is right for me?
It depends on your face, your skin and what you'd like to change. We'll recommend one at your consultation.
Do I need to massage the area afterwards?
After Sculptra, you may be advised to massage the area for about 5 minutes several times a day, for 1 to 2 weeks.
How many syringes or vials are included in the price?
We'll confirm the amount of product, your plan and your price at your consultation, before any treatment.
Related treatments
-
Dermal fillers
Hyaluronic acid filler for lips, single face areas such as cheeks and jawline, and face packages.
From £149
-
Thread lifts
Threads placed under the skin for a subtle, temporary lift, planned at a consultation.
From £399
-
Skin boosters
Injectable hyaluronic acid that may improve hydration and the look of skin texture.
From £179
How we wrote this page
Written using information from the American Academy of Dermatology, the U.S. Food and Drug Administration, the Plastic Surgery Practice and published research. Last reviewed October 2026.
- PubMed Central. A prospective, open-label, post-marketing study of the safety and effectiveness of a hyaluronic acid and calcium hydroxylapatite hybrid injectable
- PubMed Central. HArmonyCa hybrid filler to restore connective tissue: an Italian real-life retrospective study
- PubMed Central. Managing intravascular complications following treatment with calcium hydroxylapatite: an expert consensus
- American Academy of Dermatology. Fillers FAQs
- PubMed Central. Efficacy and safety of poly-L-lactic acid in facial aesthetics: a systematic review
- PubMed. Calcium hydroxylapatite: a review on safety and complications
- U.S. Food and Drug Administration. FDA-approved dermal fillers
- PubMed Central. Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé)
- PubMed Central. Guideline for the management of hyaluronic acid filler-induced vascular occlusion
- Plastic Surgery Practice. Dexlevo showcases PCL collagen stimulator data at IMCAS 2026
This page is general information, not medical advice. At your consultation, we'll talk through what's right for you.
Have a question about biostimulators?
Message us on WhatsApp, give us a call or send an enquiry with the form. Your 20-minute consultation is free, at our clinic on 8 Commerce Road, Wood Green.
Thank you.
We’ve received your enquiry and will reply on WhatsApp during our opening hours, Monday to Saturday, 10am to 7pm.
For a quicker answer, message us on WhatsApp.
WhatsApp us (opens WhatsApp)