Polynucleotides

Polynucleotides (PN) and polydeoxyribonucleotides (PDRN) are purified fragments of DNA, usually from salmon or trout. They're injected into the skin with the aim of improving how it looks and feels. PDRN is made of smaller fragments, and PN of longer ones.

They're used for crepey or thin skin, including under the eyes, fine lines and dullness. We offer five: Rejuran, Plinest, Plenhyage XL, PhilArt and Nucleofill. We'll recommend one at your consultation, based on your skin and the area.

The evidence is still developing. A review of 9 small aesthetic studies found promising effects on wrinkles, texture and elasticity, but called for better trials. So we talk about subtle, gradual change.

We'll recommend a product, or tell you if something else would suit your skin better, at your consultation.

1. 1

   Step 1: Consultation and skin check

   We talk through what you'd like to change, go through your medical history, including any allergies, and choose the product that suits you.

2. 2

   Step 2: Preparing your skin

   Your skin is cleansed and prepared.

3. 3

   Step 3: The treatment

   The product is injected into the skin in small amounts across the area.

4. 4

   Step 4: Straight afterwards

   You may see small bumps, redness or swelling at the injection points. You'll get aftercare advice for your treatment.

Common and expected

Mild, short-lived redness, small bumps, swelling or bruising at the injection points.

Less common

An allergic reaction, especially if you're allergic to fish. Please tell us about any allergies.

Rare but serious

Infection, as with any injection. The randomised trials found no serious treatment-related side effects. Contact us straight away if the area becomes hot, very painful or swollen.